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020 _a9783527348640
020 _a9783527830503
_q(electronic bk. : oBook)
020 _a3527830502
_q(electronic bk. : oBook)
020 _z9783527348640
_q(print)
020 _a9783527830527
020 _a3527830529
024 7 _a10.1002/9783527830503
_2doi
035 _a(OCoLC)1353241281
_z(OCoLC)1515469294
_z(OCoLC)1534211952
035 9 _a(OCLCCM-Owned)1353241281
040 _aDG1
_beng
_erda
_epn
_cDG1
_dOCLCF
_dOCLCO
_dCCS
_dCLOUD
_dOCLCQ
_dSFB
_dOCLCO
_dOCLCL
041 _aeng
049 _aMAIN
050 4 _aQP551.5
245 0 0 _aProtein interactions :
_bthe molecular basis of interactomics /
_cedited by Volkhard Helms and Olga V. Kalinina.
264 1 _aWeinheim, Germany :
_bWiley-VCH,
_c[2023]
300 _a1 online resource (xvi, 411 pages) :
_billustrations (some color)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aFront Matter -- Protein Structure and Conformational Dynamics / Volkhard Helms -- Protein-Protein-Binding Interfaces / Zeynep Abali, Damla Ovek, Simge Senyuz, Ozlem Keskin, Attila Gursoy -- Correlated Coevolving Mutations at Protein-Protein Interfaces / Alexander Schug -- Computational Protein-Protein Docking / Martin Zacharias -- Identification of Putative Protein Complexes in Protein-Protein Interaction Networks / Sudharshini Thangamurugan, Markus Hollander, Volkhard Helms -- Structure, Composition, and Modeling of Protein Complexes / Olga V Kalinina -- Live-Cell Structural Biology to Solve Molecular Mechanisms: Structural Dynamics in the Exocyst Function / Altair C Hernandez, Baldo Oliva, Damien P Devos, Oriol Gallego -- Kinetics and Thermodynamics of Protein-Protein Encounter / Nicolas Künzel, Volkhard Helms -- Markov State Models of Protein-Protein Encounters / Simon Olsson -- Transcription Factor - DNA Complexes / Volkhard Helms -- The Chromatin Interaction System / Sarah Kreuz, Stefan-Sebastian David, Lorena Viridiana Cortes Medina, Wolfgang Fischle -- RNA -Protein Interactomics / Cornelia Kilchert -- Interaction Between Proteins and Biological Membranes / Lorant Janosi, Alemayehu A Gorfe -- Interactions of Proteins with Small Molecules, Allosteric Effects / Michael C Hutter -- Effects of Mutations in Proteins on Their Interactions / Alexander Gress, Olga V Kalinina -- Not Quite the Same: How Alternative Splicing Affects Protein Interactions / Zakaria Louadi, Olga Tsoy, Jan Baumbach, Tim Kacprowski, Markus List -- Phosphorylation-Based Molecular Switches / Attila Reményi -- Summary and Outlook / Volkhard Helms, Olga V Kalinina.
520 _aProtein Interactions A fundamental guide to the burgeoning field of protein interactions From enzymes to transcription factors to cell membrane receptors, proteins are at the heart of biological cell function. Virtually all cellular processes are governed by their interactions, with one another, with cell bodies, with DNA, or with small molecules. The systematic study of these interactions is called Interactomics, and research within this new field promises to shape the future of molecular cell biology. Protein Interactions goes beyond any existing guide to protein interactions, presenting the first truly comprehensive overview of the field. Edited by two leading scholars in the field of protein bioinformatics, this book covers all known categories of protein interaction, stable as well as transient, as well as the effect of mutations and post-translational modifications on the interaction behavior. Protein Interactions readers will also find: Introductory chapters on protein structure, conformational dynamics, and protein-protein binding interfaces A data-driven approach incorporating machine learning and integrating experimental data into computational models An outlook on the current challenges in the field and suggestions for future research Protein Interactions will serve as a fundamental resource for novice researchers who want a systematic introduction to interactomics, as well as for experienced cell biologists and bioinformaticians who want to gain an edge in this exciting new field.
588 0 _aOnline resource; title from PDF title page (John Wiley, viewed December 5, 2022).
650 0 _aProtein-protein interactions.
_0http://id.loc.gov/authorities/subjects/sh2003008324
650 0 _aMolecular biology.
_0http://id.loc.gov/authorities/subjects/sh85086577
650 6 _aInteractions protéine-protéine.
650 6 _aBiologie moléculaire.
650 7 _amolecular biology.
_2aat
650 7 _aBiochemistry.
_2bisacsh/2022
650 7 _aBiostatistics.
_2bisacsh/2022
650 7 _aMEDICAL.
_2bisacsh/2022
650 7 _aCell Biology.
_2bisacsh/2022
650 7 _aLife Sciences.
_2bisacsh/2022
650 7 _aSCIENCE.
_2bisacsh/2022
650 7 _aProtein-protein interactions
_2fast
655 4 _aElectronic books.
700 1 _aHelms, Volkhard,
_eeditor.
700 1 _aKalinina, Olga V.,
_eeditor.
776 0 8 _iPrint version:
_aHelms, Volkhard
_tProtein Interactions
_dNewark : John Wiley & Sons, Incorporated,c2023
_z9783527348640
856 4 0 _uhttps://onlinelibrary.wiley.com/doi/book/10.1002/9783527830503
_yFull text is available at Wiley Online Library. Click here to view.
942 _2ddc
_cER