000 04081nam a2200445Ii 4500
001 1262663232
003 OCoLC
005 20250318163920.0
006 m o d
007 cr cnu|||unuuu
008 210803s2021 njum ob u001 0 eng d
020 _a9781119171003
_q(electronic bk. : oBook)
020 _a1119171008
_q(electronic bk. : oBook)
020 _z9781119170846
024 7 _a10.1002/9781119171003
_2doi
035 _a(OCoLC)1262663232
040 _aDG1
_beng
_erda
_epn
_cDG1
_dOCLCO
050 4 _aRA1238
082 0 4 _a615.7/042
_223
245 0 0 _aTransporters and drug-metabolizing enzymes in drug toxicity /
_cEdited by Albert P. Li.
264 1 _aHoboken, NJ :
_bWiley,
_c2021.
300 _a1 online resource.
336 _atext
_btxt
_2rdacontent.
337 _acomputer
_bc
_2rdamedia.
338 _aonline resource
_bcr
_2rdacarrier.
340 _gpolychrome
_2rdacc
_0http://rdaregistry.info/termList/RDAColourContent/1003.
505 0 _aOverview. Overview / Albert P Li -- Transporter, Drug Metabolism, and Drug-Induced Liver Injury in Marketed Drugs / Minjun Chen, Kristin Ashby, Yue Wu -- Drug-Metabolism Enzymes and Transporter Activities as Risk Factors of Selected Marketed Drugs Associated with Drug-Induced Fatalities / Albert P Li -- Drug Metabolizing Enzymes and Drug Toxicity. Drug-Metabolizing Enzymes and Drug Toxicity / Albert P Li -- Genetic Polymorphism of Drug-Metabolizing Enzymes and Drug Transporters in Drug Toxicity / Ann K Daly -- Acyl Glucuronidation and Acyl-CoA Formation Mechanisms Mediating the Bioactivation and Potential Toxicity of Carboxylic Acid-containing Drugs / Mark P Grillo -- Liquid Chromatography-Mass Spectrometry (LC-MS) Quantification of Reactive Metabolites / Qingping Wang, Chuang Lu -- Human-Based In Vitro Experimental Approaches for the Evaluation of Metabolism-Dependent Drug Toxicity / Albert P Li -- Drug Transporters and Drug Toxicity. Mechanism-Based Experimental Models for the Evaluation of BSEP Inhibition and DILI / William A Murphy, Chitra Saran, Paavo Honkakoski, Kim LR Brouwer -- Hepatic Bile Acid Transporters in Drug-Induced Cholestasis / Tao Hu, Hongbing Wang -- Role of Renal Transporters in Drug-Drug Interactions and Nephrotoxicity / Yan Zhang, Donald Miller -- Blood-Brain Barrier Transporters and Central Nervous System Drug Response and Toxicity / Donald W Miller, Stacey Line, Nur A Safa, Yan Zhang -- Ototoxicity and Drug Transport in the Cochlea / Stefanie Kennon-McGill, Mitchell R McGill -- Modeling Drug Metabolizing Enzymes-Transporters Interplay for The Prediction of Drug Toxicity. Application of a PBPK Model Incorporating the Interplay Between Transporters and Drug-Metabolizing Enzymes for the Precise Prediction of Drug Toxicity / Kazuya Maeda -- The Extended Clearance Model / Birk Poller, Felix Huth, Vlasia Kastrinou-Lampou, Gerd A Kullak-Ublick, Michael Arand, Gian Camenisch.
504 _aIncludes bibliographical references and index.
506 _aAvailable to OhioLINK libraries.
520 _aThis book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions.
650 0 _aDrugs
_xToxicology.
_0http://id.loc.gov/authorities/subjects/sh85039757.
655 4 _aElectronic books.
700 1 _aLi, A. P.,
_0http://id.loc.gov/authorities/names/n84176143
_eeditor.
710 2 _aOhio Library and Information Network.
_0http://id.loc.gov/authorities/names/no95058981.
856 4 0 _3OhioLINK
_zConnect to resource
_uhttps://rave.ohiolink.edu/ebooks/ebc2/9781119171003
856 4 0 _3Wiley Online Library
_zConnect to resource
_uhttps://onlinelibrary.wiley.com/doi/book/10.1002/9781119171003
856 4 0 _3Wiley Online Library
_zConnect to resource (off-campus)
_uhttps://go.ohiolink.edu/goto?url=https://onlinelibrary.wiley.com/doi/book/10.1002/9781119171003
913 _aN
989 7 _atransporters_and_drug_metabolizing_enzymes_indtoxicity___________2021_______wia_______________________________
999 _c89810
_d89810