TY  - BOOK
AU  - Li,A.P.
ED  - Ohio Library and Information Network.
TI  - Transporters and drug-metabolizing enzymes in drug toxicity
SN  - 9781119171003
AV  - RA1238 
U1  - 615.7/042 23
PY  - 2021///
CY  - Hoboken, NJ
PB  - Wiley
KW  - Drugs
KW  - Toxicology
KW  - Electronic books
N1  - Includes bibliographical references and index; Overview. Overview / Albert P Li -- Transporter, Drug Metabolism, and Drug-Induced Liver Injury in Marketed Drugs / Minjun Chen, Kristin Ashby, Yue Wu -- Drug-Metabolism Enzymes and Transporter Activities as Risk Factors of Selected Marketed Drugs Associated with Drug-Induced Fatalities / Albert P Li -- Drug Metabolizing Enzymes and Drug Toxicity. Drug-Metabolizing Enzymes and Drug Toxicity / Albert P Li -- Genetic Polymorphism of Drug-Metabolizing Enzymes and Drug Transporters in Drug Toxicity / Ann K Daly -- Acyl Glucuronidation and Acyl-CoA Formation Mechanisms Mediating the Bioactivation and Potential Toxicity of Carboxylic Acid-containing Drugs / Mark P Grillo -- Liquid Chromatography-Mass Spectrometry (LC-MS) Quantification of Reactive Metabolites / Qingping Wang, Chuang Lu -- Human-Based In Vitro Experimental Approaches for the Evaluation of Metabolism-Dependent Drug Toxicity / Albert P Li -- Drug Transporters and Drug Toxicity. Mechanism-Based Experimental Models for the Evaluation of BSEP Inhibition and DILI / William A Murphy, Chitra Saran, Paavo Honkakoski, Kim LR Brouwer -- Hepatic Bile Acid Transporters in Drug-Induced Cholestasis / Tao Hu, Hongbing Wang -- Role of Renal Transporters in Drug-Drug Interactions and Nephrotoxicity / Yan Zhang, Donald Miller -- Blood-Brain Barrier Transporters and Central Nervous System Drug Response and Toxicity / Donald W Miller, Stacey Line, Nur A Safa, Yan Zhang -- Ototoxicity and Drug Transport in the Cochlea / Stefanie Kennon-McGill, Mitchell R McGill -- Modeling Drug Metabolizing Enzymes-Transporters Interplay for The Prediction of Drug Toxicity. Application of a PBPK Model Incorporating the Interplay Between Transporters and Drug-Metabolizing Enzymes for the Precise Prediction of Drug Toxicity / Kazuya Maeda -- The Extended Clearance Model / Birk Poller, Felix Huth, Vlasia Kastrinou-Lampou, Gerd A Kullak-Ublick, Michael Arand, Gian Camenisch; Available to OhioLINK libraries
N2  - This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions
UR  - https://rave.ohiolink.edu/ebooks/ebc2/9781119171003
UR  - https://onlinelibrary.wiley.com/doi/book/10.1002/9781119171003
UR  - https://go.ohiolink.edu/goto?url=https://onlinelibrary.wiley.com/doi/book/10.1002/9781119171003
ER  -