TY - BOOK AU - Spector,Peter TI - Understanding atrial fibrillation SN - 9781119524601 AV - RC685.A72 U1 - 616.1/28 23 PY - 2020/// CY - Hoboken, NJ PB - Wiley-Blackwell KW - Atrial Fibrillation KW - physiopathology KW - diagnosis KW - Electrophysiologic Techniques, Cardiac KW - methods KW - Cardiac Electrophysiology KW - Models, Cardiovascular KW - Electronic books N1 - ABOUT THE AUTHOR Peter Spector, MD, is Professor of Medicine, Professor of Electrical and Biomedical Engineering, and Director of Cardiac Electrophysiology and the Cardiac Electrophysiology Laboratory at the University of Vermont Medical Center, Burlington, VT, USA; Includes bibliographical references and index; TABLE OF CONTENTS Preface ix Acknowledgments xiii Part I: Building blocks of fibrillation 1 Excitation and propagation 1 Source-sink relationships 2 What determines source-sink balance? 3 Propagation and reentry 4 Requirements for reentry 4 What makes a circuit? 6 Source-sink balance and rotors 6 Wave length 8 Wave length, path length, and reentry 9 Restitution 10 Initiating reentry 11 Part II: Atrial fibrillation mechanisms 21 The evolution of current concepts 21 The mass hypothesis of atrial fibrillation 30 Principles of propagation: Implications for fibrillation 32 Focal rotors 52 Micro‐reentry 55 Fibrillatory conduction or multi‐wavelet reentry? 66 Location of atrial fibrillation drivers 76 Principles of propagation: Driver interactions in fibrillation 87 Part III: Working with incomplete information 93 Cardiac mapping 93 Sample density and atrial fibrillation 115 What should we do with the patient who comes to the lab tomorrow? Putting it all together (without “it all”) 128 Putting it all together: Atrial fibrillation in three questions 132 Appendix A: Calculating probability in a random walk 135 Appendix B: Dominant frequency analysis 137 Appendix C: A stupid idea, but a learning opportunity 143 References 149 Index 161 N2 - "Physicians today are being presented with voluminous and conflicting information about the mechanisms responsible for AF, the tools to identify its drivers and the strategies appropriate for its treatment. This book is meant to provide physicians with the information and analytic tools required interpret the studies that purport to solve the AF puzzle. The aim of the book is to 1) explain the mechanisms responsible for initiating and perpetuating AF by building from fundamental electrophysiologic principles, 2) review the experimental data that has shaped our current understanding of AF, 3) describe the analytic methods used to interpret the experimental data, 4) explore the implications that the above information has with regard to mapping and ablation of AF. The book will be written from first principles, it is designed for readers with a foundation in electrophysiology. The intended audience is physicians, fellows, residents, electrophysiology lab staff and industry personnel interested in treating atrial fibrillation"--Provided by publisher UR - https://onlinelibrary.wiley.com/doi/book/10.1002/9781119524632 ER -