Drug metabolism handbook : concepts and applications in cancer research / edited by Ala F. Nassar ; associate editors Paul F. Hollenberg [and three others]

Includes bibliographical references and index.

Front Matter -- Introduction. Historical Perspective / ROBERTA S KING -- Factors Affecting Metabolism / ROBERTA S KING -- Biotransformations in Drug Metabolism / ROBERTA S KING -- A Comprehensive Picture of Biotransformation in Drug Discovery / JOE R CANNON, PRAKASH VACHASPATI, YANG YUAN -- In Vivo Drug Metabolite Kinetics / ZHENG YANG -- LC-MS / MS -Based Proteomics Methods for Quantifying Drug-Metabolizing Enzymes and Transporters / Logan S Smith, SUN MIN JUNG, JIAPENG LI, HAO-JIE ZHU -- Technologies for In vitro and In vivo Studies. Mass Spectrometry / THOMAS R SHARP -- Accelerating Metabolite Identification Mass Spectrometry Technology Drives Metabolite Identification Studies Forward / ALA F NASSAR -- Role of Structural Modifications of Drug Candidates to Enhance Metabolic Stability / ALA F Nassar -- Drug Design Strategies: Role of Structural Modifications of Drug Candidates to Improve PK Parameters of New Drugs / ALA F NASSAR -- Chemical Structural Alert and Reactive Metabolite Concept as Applied in Medicinal Chemistry to Minimize the Toxicity of Drug Candidates / ALA F NASSAR -- Studies of Reactive Metabolites using Genotoxicity Arrays and Enzyme/ DNA Biocolloids - 2021 / JAMES F RUSLING, ELI G HVASTKOVS -- Drug Interactions. Enzyme Inhibition / PAUL F HOLLENBERG -- Xenobiotic Receptor-Mediated Gene Regulation in Drug Metabolism and Disposition / HONGBING WANG, WEN XIE -- Characterization of Cytochrome P450 Mechanism Based Inhibition / DAN A ROCK, LARRY C WIENKERS -- An Introduction to Metabolic Reaction-Phenotyping / CARL DAVIS -- Epigenetic Regulation of Drug-Metabolizing Enzymes in Cancer / JIAQI WANG, XIAOLI ZHENG, SU ZENG -- Epigenetic Regulation of Drug Transporters in Cancer / YINGYING WANG, YING ZHOU, YU WANG, LUSHAN YU, SU ZENG -- Toxicity. The Role of Drug Metabolism in Toxicity / UMESH M HANUMEGOWDA, CARL DAVIS -- Allergic Reactions to Drugs / MARK P GRILLO -- Chemical Mechanisms in Toxicology / MARK P GRILLO -- Role of Bioactivation Reactions in Chemically Induced Nephrotoxicity / LAWRENCE H LASH -- Applications. Mapping the Heterogeneous Distribution of Cancer Drugs by Imaging Mass Spectrometry / PURVA S DAMALE, SHIBDAS BANERJEE -- Systemic Metabolomic Changes Associated with Chemotherapy: Role in Personalized Therapy / BHARGAB KALITA, GANESH K BARIK, TANISHA SHARMA, KHUSHMAN TAUNK, PRANEETA P BHAVSAR, MANAS K SANTRA, SRIKANTH RAPOLE -- Metabolic Reprogramming in Cancer / DEBASISH PRUSTY, Soumen Kanti Manna -- Case Study: Metabolism and Reactions of Alkylating Agents in Cancer Therapy / ALA F NASSAR, ADAM V WISNEWSKI, IVAN KING -- Rewiring of Drug Metabolism and Its Cross-talk with Metabolic Reprogramming in Cancer / SUBHABRATA MAJUMDER, Soumen Kanti Manna -- Principles of Drug Metabolism and Interactions in Cardio-Oncology / SHERRY-ANN BROWN, CRAIG BEAVERS, SAILAJA KAMARAJU, MEERA MOHAN, OLUBADEWA FATUNDE, GIFT ECHEFU, SVETLANA ZAHAROVA, BRIANNA WALLACE, CAROLYN OXENCIS -- Index.

A comprehensive explanation of drug metabolism concepts and applications in drug development and cancer treatment

In the newly revised second edition of Drug Metabolism Handbook: Concepts and Applications in Cancer Research, a distinguished team of researchers delivers an incisive and robust exploration of the drug metabolism system and a well-illustrated and detailed explanation of the latest tools and techniques used in the research, pharmacology, and medicine. The book discusses the creation of new molecular entities, drug development, troubleshooting, and other highly relevant concepts, guiding readers through new applications in pharmaceutical research, development, and assessment.

The latest edition offers updated content on metabolism basics and the application of a variety of new techniques to cancer treatment, including mass spectrometry, imaging, metabolomics, and immunotherapy. It also offers in-depth case studies highlighting the role of metabolism in drug development.

Readers will also benefit from:

A thorough introduction to drug metabolism, including a historical perspective, factors affecting metabolism, and biotransformations in drug metabolism
Comprehensive discussions of technologies for in vitro and in vivo studies, including mass spectrometry and accelerating metabolite identification with mass spectrometry
In-depth explorations of drug interactions, including discussions of enzyme inhibition and the characterization of cytochrome P450 mechanism-based inhibition
Fulsome treatments of drug toxicity, including the role of drug metabolism in toxicity, and allergic reactions to drugs
Perfect for medicinal chemists, pharmaceutical scientists, and toxicologists, Drug Metabolism Handbook: Concepts and Applications in Cancer Research, Second Edition will also earn a place in the libraries of analytical chemists and drug discovery professionals.

About the Author
Ala F. Nassar, PhD, is a faculty member at Yale University. He leads and executes ADME-Tox experiments supporting grant projects. He has served on numerous editorial boards and is the editor of the previous edition of Drug Metabolism Handbook: Concepts and Applications and Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification.

Paul F. Hollenberg, PhD, was the Maurice H. Seevers Professor and Chair of Pharmacology at the University of Michigan for more than 20 years. His research focused on the active sites of P450s and their catalytic function. He was cofounder and Associate Editor of Chemical Research in Toxicology and has served on numerous editorial boards and review panels.

JoAnn Scatina, PhD has over 30 years of experience in Drug Metabolism and Preclinical Drug Development with leadership roles in both big pharma (Wyeth) and smaller biotech firms. She also provides expert drug development advice as a consultant to biotech and academic institutions.

Soumen Kanti Manna, PhD, is an Associate Professor in the Biophysics and Structural Genomics Division of Saha Institute of Nuclear Physics, Kolkata. His doctoral work involved cytochrome P450 and other metalloproteins. His current research activities include unravelling of metabolic reprogramming associated with gene-environment interaction and cancer as well as RNA modification and biomarker discovery.

Su Zeng, PhD, is a Professor and Director of Institute of Drug Metabolism and Pharmaceutical Analysis at College of Pharmaceutical Sciences, Zhejiang University. His research focuses on the regulation mechanism of drug ADME-Tox by using epigenetic models, transgenic cells expressing drug metabolizing enzymes, or transporters.