Bone and joint infections : from microbiology to diagnostics and treatment / editor, Werner Zimmerli.

ABOUT THE AUTHOR
Werner Zimmerli is Professor Emeritus in Internal Medicine and Infectious Diseases and Consultant for Orthopedic Infections at the Kantonsspital Baselland/Liestal. His primary research focus is on implant-associated infections. He is also the co-publisher of an algorithm on the surgical management of periprosthetic joint infection.

Includes bibliographical references and index.

Diagnostic Approach in Bone and Joint Infections -- Unusual Microorganisms in Periprosthetic Joint Infection -- Identification of Pathogens in Bone and Joint Infections by Non-Culture Techniques -- Bacteriophages for treatment of biofilm infections -- Pharmacokinetics and Pharmacodynamics of Antibiotics in Bone -- Preclinical Models of Infection in Bone and Joint Surgery -- Native Joint Arthritis in Children -- Native Joint Arthritis in Adults -- Septic Arthritis of Axial Joints -- Periprosthetic Joint Infection : General Aspects -- Periprosthetic Joint Infection after Total Hip and Knee Arthroplasty -- Periprosthetic Joint Infection after Shoulder Arthroplasty -- Periprosthetic Joint Infection after Elbow Arthroplasty -- Periprosthetic Joint Infection after Ankle Arthroplasty -- Osteomyelitis : Classification -- Osteomyelitis in Children -- Acute Osteomyelitis in Adults -- Subacute Osteomyelitis : Tuberculous and Brucellar Vertebral Osteomyelitis -- Chronic Osteomyelitis in Adults -- Diabetic Foot Osteomyelitis -- Osteomyelitis of the Jaws -- Fracture-related Infection of Long Bones -- Implant-Associated Vertebral Osteomyelitis -- Postoperative Sternal Osteomyelitis.

"The prevalence of most bone and joint infections is steadily increasing, mainly due to the rising life expectancy of the population, and the increasing use of bone fixation devices and prosthetic joints. For frequent infectious diseases, such as respiratory tract, urinary tract and bloodstream infections, many diagnostic and therapeutic aspects have been studied in a controlled fashion [e.g. 1-3]. In contrast, in the field of bone and joint infections, randomized controlled trials are rare. Exceptions are a randomized controlled study on the role of rifampin in patients with orthopedic implant-associated infections, and a controlled trial comparing two different durations of antibiotic treatment in patients with vertebral osteomyelitis [4, 5]. Therefore, diagnostic and therapeutic advice has to be based mainly on individual clinical expert knowledge and observational studies [6-10]. The optimal diagnostic and therapeutic management of bone and joint infections needs a special know-how in different fields of medicine. Many physicians have only limited clinical experience, since arthritis and osteomyelitis are rare infectious diseases. Therefore, a multidisciplinary approach to these infections is desirable. Only for a few topics, internationally accepted guidelines for the management of bone and joint infections are available [11-13]. In addition, publications on the clinical practice comprising different aspects of these infections are scarce. The aim of this book is to close this gap with texts from a multidisciplinary team of experts in the field. Indeed, specialists in Microbiology, Clinical Pharmacology, Preclinical Research, Pediatrics, Pediatric and Adult Orthopedic Surgery, Infectious Diseases, and Cardiovascular Surgery contributed to this book. This broad spectrum of expertise made it possible to cover a wide range of pathophysiological, epidemiological, diagnostic and therapeutic aspects of bone and joint infection. The principal focus of the book is on clinical practice. It should enable clinicians managing patients according to the best available evidence"-- Provided by publisher.

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